A semi-decentralized control strategy for urban traffic

We present in this article a semi-decentralized approach for urban traffic control, based on the TUC (Traffic responsive Urban Control) strategy. We assume that the control is centralized as in the TUC strategy, but we introduce a contention time window inside the cycle time, where antagonistic stages alternate a priority rule. The priority rule is set by applying green colours for given stages and yellow colours for antagonistic ones, in such a way that the stages with green colour have priority over the ones with yellow colour. The idea of introducing this time window is to reduce the red time inside the cycle, and by that, increase the capacity of the network junctions. In practice, the priority rule could be applied using vehicle-to-vehicle (v2v) or vehicle-to-infrastructure (v2i) communications. The vehicles having the priority pass almost normally through the junction, while the others reduce their speed and yield the way. We propose a model for the dynamics and the control of such a system. The model is still formulated as a linear quadratic problem, for which the feedback control law is calculated off-line, and applied in real time. The model is implemented using the Simulation of Urban MObility (SUMO) tool in a small regular (American-like) network configuration. The results are presented and compared to the classical TUC strategy.Comment: 16 page

Genome-wide identification, characterization, and expression analysis of the Chalcone Synthase gene family in Oryza sativa under Abiotic Stresses

Chalcone synthase (CHS) is the pivotal enzyme that catalyzes the first committed step of the phenylpropanoid pathway leading to flavonoids. Herein, we identified twenty-seven OsCHS genes from the rice genome database. The bioinformatics analysis, including conserved motif, domain, interactive proteins, gene ontology (GO), target micro RNAs (miRNA) prediction, and the OsCHS physiochemical properties, highlight the key aspects of OsCHS genes in Oryza sativa L. The OsCHS proteins' phylogeny was further clustered into 4 sub-groups (Group I- Group IV) based on the structural similarities and functional diversities. The GO analysis of OsCHS proteins showed they are highly stress-responsive (biotic/abiotic) and involved in various growth and developmental processes. The microarray expression analysis showed transcription in twelve rice tissues, and the differential expression pattern of OsCHS genes revealed their possible involvement against salinity and drought. The higher expression of OsCHS15 in the OsWRKY65-OE line indicates its potential in hormonal-mediated stress response. The predicted miRNA that includes miR2260, miR167, miR11337, and miR2232 families further the engagement of OsCHS genes in the post-translational regulation of rice growth and stress-responsive. Owing to the above-mentioned outcomes, we speculate that OsCHS genes in the O. sativa genome play an essential role not only in growth and development but also in fine-tuning the immune responses to various environmental stresses and provide major indications for further functional studies

Design of a Reliable XOR-XNOR Circuit for Arithmetic Logic Units

Part 12: DATICSInternational audienceComputer systems used in safety-critical applications like space, avionic and biomedical applications require high reliable integrated circuits (ICs) to ensure the accuracy of data they process. As Arithmetic Logic Units (ALUs) are essential element of computers, designing reliable ALUs is becoming an appropriate strategy to design fault-tolerant computers. In fact, with the continuous increase of integration densities and complexities ICs are susceptible to many modes of failure. Thereby, Reliable operation of ALUs is critical for high performance safety-critical computers. Given that XOR-XNOR circuits are basic building blocks in ALUs, designing efficient reliable XOR-XNOR gates is an important challenge in the area of high performance computers. The reliability enhancement technique presented in this work is based on using a Concurrent Error Detection (CED) based reliable XOR-XNOR circuit implementation to detect permanent and transient faults in ALUs during normal operation in order to improve the reliability of highly critical computer systems. The proposed design is performed using the 32 nm process technology

A Self-test and self-repair approach for analog integrated circuits

With the continuous increase of integration densities and complexities, secure integrated circuits (ICs) are more and more required to guarantee reliability for safety-critical applications in the presence of soft and hard faults. Thus, testing has become a real challenge for enhancing the reliability of safety-critical systems. This paper presents a Self-Test and Self- Repair approach which can be used to tolerate the most likely defects of bridging type that create a resistive path between VDD supply voltage and the ground occurring in analog CMOS circuits during the manufacturing process. The proposed testing approach is designed using the 65 nm CMOS technology. We then used an operational amplifier (OPA) to validate the technique and correlate it with post layout simulation resultsTaikomosios informatikos katedraVytauto Didžiojo universiteta

Outcomes of therapeutic plasma exchange in severe autoimmune hemolytic anemia hospitalizations: An analysis of the National Inpatient Sample

BACKGROUND: Autoimmune hemolytic anemia (AIHA) is characterized by humoral and/or cellular immune-mediated hemolysis of red blood cells. The role of therapeutic plasma exchange (TPE) in AIHA is unclear. STUDY DESIGN AND METHODS: We queried the National Inpatient Sample (NIS) for 2002-2019 to identify hospitalizations with the primary diagnosis of AIHA. We included hospitalizations with the highest severity subclass identified by All Patient Refined Disease Related Group (APR-DRG). We used multivariate regression analysis to compare in-hospital mortality and other relevant in-hospital outcomes between hospitalizations that received TPE and those that did not. RESULTS: We identified 255 weighted hospitalizations in the TPE group and 4973 in the control group. Those in the control group were older (median age 67 vs. 48 years, p \u3c .001) and had a higher prevalence of most comorbidities. The TPE group had higher odds of all-cause in-hospital mortality (odds ratio [OR], 1.59; 95% confidence interval [CI], 1.19-2.11). They also had higher rates of many secondary outcomes, including requiring mechanical ventilation, developing circulatory shock, acute stroke, urinary tract infections, intracranial hemorrhage, acute kidney injury, and requiring new hemodialysis. No significant differences were noted in the rates of acute myocardial infarctions, bacterial pneumonia, sepsis/septicemia, thromboembolic events, and other bleeding events. Furthermore, the TPE group had a higher median length of hospital stay (19 vs. 9 days, p \u3c .001). CONCLUSION: Hospitalizations with severe AIHA that received TPE had higher rates of adverse in-hospital outcomes

Outcomes of therapeutic plasma exchange in severe autoimmune hemolytic anemia hospitalizations: An analysis of the National Inpatient Sample

BACKGROUND: Autoimmune hemolytic anemia (AIHA) is characterized by humoral and/or cellular immune-mediated hemolysis of red blood cells. The role of therapeutic plasma exchange (TPE) in AIHA is unclear. STUDY DESIGN AND METHODS: We queried the National Inpatient Sample (NIS) for 2002-2019 to identify hospitalizations with the primary diagnosis of AIHA. We included hospitalizations with the highest severity subclass identified by All Patient Refined Disease Related Group (APR-DRG). We used multivariate regression analysis to compare in-hospital mortality and other relevant in-hospital outcomes between hospitalizations that received TPE and those that did not. RESULTS: We identified 255 weighted hospitalizations in the TPE group and 4973 in the control group. Those in the control group were older (median age 67 vs. 48 years, p \u3c .001) and had a higher prevalence of most comorbidities. The TPE group had higher odds of all-cause in-hospital mortality (odds ratio [OR], 1.59; 95% confidence interval [CI], 1.19-2.11). They also had higher rates of many secondary outcomes, including requiring mechanical ventilation, developing circulatory shock, acute stroke, urinary tract infections, intracranial hemorrhage, acute kidney injury, and requiring new hemodialysis. No significant differences were noted in the rates of acute myocardial infarctions, bacterial pneumonia, sepsis/septicemia, thromboembolic events, and other bleeding events. Furthermore, the TPE group had a higher median length of hospital stay (19 vs. 9 days, p \u3c .001). CONCLUSION: Hospitalizations with severe AIHA that received TPE had higher rates of adverse in-hospital outcomes

Isolation and characterization of two glycolipopeptids biosurfactants produced by a Lactiplantibacillus plantarum OL5 strain isolated from green olive curing water

Microbial surfactants are natural amphiphilic compounds with high surface activities and emulsifying properties. Due to their structural diversity, low toxicity, biodegradability, and chemical stability in different conditions, these molecules are potential substitutes for chemical surfactants; their interest has grown significantly over the last decade. The current study focuses on the isolation, identification, and characterization of a lactic acid bacteria that produce two forms of biosurfactants. The OL5 strain was isolated from green olive fermentation and identified using MALDI/TOF and DNAr16S amplification. Emulsification activity and surface tension measurements were used to estimate biosurfactant production. The two biosurfactants derived from Lactiplantibacillus plantarum OL5 presented good emulsification powers in the presence of various oils. They were also shown to have the potential to reduce water surface tension from 69 mN/m to 34 mN/m and 37 mN/m within a critical micelle concentration (CMC) of 7 mg/ml and 1.8 mg/ml, respectively, for cell bound and extracellular biosurfactants. Thin layer chromatography (TLC) and FT-IR were used to analyze the composition of the two biosurfactants produced. the obtained data revealed that the two biomolecules consist of a mixture of carbohydrates, lipids and proteins. We demonstrated that they are two anionic biosurfactants with glycolipopeptide nature which are stable in extreme conditions of temperature, pH and salinity.This work was supported by the Ministry of High Education and Scientific Research- Tunisia

Relation of outcomes to ABC (Atrial Fibrillation Better Care) pathway adherent care in European patients with atrial fibrillation: an analysis from the ESC-EHRA EORP Atrial Fibrillation General Long-Term (AFGen LT) Registry

International audienceAbstract Aims There has been an increasing focus on integrated, multidisciplinary, and holistic care in the treatment of atrial fibrillation (AF). The ‘Atrial Fibrillation Better Care’ (ABC) pathway has been proposed to streamline integrated care in AF. We evaluated the impact on outcomes of an ABC adherent management in a contemporary real-life European-wide AF cohort. Methods and results Patients enrolled in the ESC-EHRA EURObservational Research Programme in AF General Long-Term Registry with baseline data to evaluate ABC criteria and available follow-up data were considered for this analysis. Among the original 11 096 AF patients enrolled, 6646 (59.9%) were included in this analysis, of which 1996 (30.0%) managed as ABC adherent. Patients adherent to ABC care had lower CHA2DS2-VASc and HAS-BLED scores (mean ± SD, 2.68 ± 1.57 vs. 3.07 ± 1.90 and 1.26 ± 0.93 vs. 1.58 ± 1.12, respectively; P < 0.001). At 1-year follow-up, patients managed adherent to ABC pathway compared to non-adherent ones had a lower rate of any thromboembolic event (TE)/acute coronary syndrome (ACS)/cardiovascular (CV) death (3.8% vs. 7.6%), CV death (1.9% vs. 4.8%), and all-cause death (3.0% vs. 6.4%) (all P < 0.0001). On Cox multivariable regression analysis, ABC adherent care showed an association with a lower risk of any TE/ACS/CV death [hazard ratio (HR): 0.59, 95% confidence interval (CI): 0.44–0.79], CV death (HR: 0.52, 95% CI: 0.35–0.78), and all-cause death (HR: 0.57, 95% CI: 0.43–0.78). Conclusion In a large contemporary cohort of European AF patients, a clinical management adherent to ABC pathway for integrated care is associated with a significant lower risk for cardiovascular events, CV death, and all-cause death